530650 Luciferase Substrate, CycLuc1 - Calbiochem

530650
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃H₁₁N₃O₂S₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.30650.0001
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          Glass bottle 10 mg
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          Description
          OverviewA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530650
          Brand Family Calbiochem®
          References
          ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
          Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
          Product Information
          FormYellow powder
          Hill FormulaC₁₃H₁₁N₃O₂S₂
          Chemical formulaC₁₃H₁₁N₃O₂S₂
          Applications
          Biological Information
          Primary TargetLuciferase
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Luciferase Substrate, CycLuc1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Luciferase Substrate, CycLuc1 - Calbiochem Certificates of Analysis

          TitleLot Number
          530650

          References

          Reference overview
          Evans, M., et al. 2014. Nat Methods. 11, 393.
          Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2019 JSW
          DescriptionA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃H₁₁N₃O₂S₂
          Purity≥94% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
          Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.