437627 Lipopolysaccharide, E. coli O111: B4 - Calbiochem

437627
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      437627-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
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          Will advise
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          Plastic ampoule 5 mg
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          Description
          OverviewStimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
          Catalogue Number437627
          Brand Family Calbiochem®
          References
          ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
          Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
          Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
          Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
          Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
          Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
          O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
          Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
          Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          ReversibleN
          Applications
          Biological Information
          Primary TargetInducible nitric oxide synthase
          Physicochemical Information
          Cell permeableN
          ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSOJ0895400
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          437627

          References

          Reference overview
          Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
          Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
          Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
          Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
          Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
          Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
          O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
          Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
          Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2008 JSW
          DescriptionEndotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxic shock, a profound life-threatening consequence of sepsis. More recently, these bacterial products have generated intense interest due to their pluropotential immunostimulatory activity as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cell activation by lipopolysaccharides produces a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor, and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
          FormLyophilized
          RTECSOJ0895400
          ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
          SolubilityH₂O (5 mg/ml) or 0.5% triethylamine (1 mg/ml). To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Harmful
          ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
          Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
          Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
          Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
          Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
          Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
          O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
          Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
          Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.