426100 | Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem

426100
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₄N₂O₇S 1258004-00-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      426100-1MG
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          Glass bottle 1 mg
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          426100-200UG
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              Plastic ampoule 200 μg
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              426100-400UG
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                  Plastic ampoule 400 μg
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                  Description
                  OverviewAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM).
                  Catalogue Number426100
                  Brand Family Calbiochem®
                  SynonymsProteasome Inhibitor VI
                  References
                  ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
                  Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
                  Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
                  Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
                  Fenteany, G., et al. 1995. Science 268, 726.
                  Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
                  Jensen, T.J., et al. 1995. Cell 83, 129.
                  Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
                  Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
                  Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
                  Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
                  Omura, S., et al. 1991. J. Antibiot. 44, 117.
                  Product Information
                  CAS number1258004-00-0
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₁₅H₂₄N₂O₇S
                  Chemical formulaC₁₅H₂₄N₂O₇S
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary Target20S proteasome (MCP; multicatalytic proteinase complex)
                  Primary Target IC<sub>50</sub>500 nM against 20S proteasome; 10 µM against NF-κB activation
                  Purity≥99% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  426100

                  References

                  Reference overview
                  Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
                  Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
                  Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
                  Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
                  Fenteany, G., et al. 1995. Science 268, 726.
                  Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
                  Jensen, T.J., et al. 1995. Cell 83, 129.
                  Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
                  Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
                  Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
                  Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
                  Omura, S., et al. 1991. J. Antibiot. 44, 117.

                  Brochure

                  Title
                  Proteasomes Technical Bulletin

                  Citations

                  Title
                • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
                • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
                • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision23-October-2012 JSW
                  SynonymsProteasome Inhibitor VI
                  DescriptionAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM)
                  FormWhite solid
                  CAS number1258004-00-0
                  Chemical formulaC₁₅H₂₄N₂O₇S
                  Structure formulaStructure formula
                  Purity≥99% by HPLC
                  SolubilityDMSO (50 mg/ml) or H₂O
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
                  Toxicity Standard Handling
                  ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
                  Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
                  Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
                  Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
                  Fenteany, G., et al. 1995. Science 268, 726.
                  Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
                  Jensen, T.J., et al. 1995. Cell 83, 129.
                  Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
                  Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
                  Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
                  Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
                  Omura, S., et al. 1991. J. Antibiot. 44, 117.
                  Citation
                • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
                • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
                • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.