504466 | LY-404,039 - CAS 635318-55-7 - Calbiochem

504466
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₉NO₆S 635318-55-7

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04466.0001
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          Glass bottle 5 mg
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          Description
          OverviewA highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
          Catalogue Number504466
          Brand Family Calbiochem®
          Synonyms(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
          References
          ReferencesSeeman, P., 2013. Neuropharmacology. 66, 87.
          Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
          Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
          Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
          Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.
          Product Information
          CAS number635318-55-7
          FormWhite powder
          Hill FormulaC₇H₉NO₆S
          Chemical formulaC₇H₉NO₆S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₂ & mGlu₃
          Primary Target K<sub>i</sub>149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.
          Purity≥98% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Seeman, P., 2013. Neuropharmacology. 66, 87.
          Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
          Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
          Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
          Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
          DescriptionA highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
          FormWhite powder
          CAS number635318-55-7
          Chemical formulaC₇H₉NO₆S
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (0.25 mg/ml) or dilute NaOH (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
          Toxicity Standard Handling
          ReferencesSeeman, P., 2013. Neuropharmacology. 66, 87.
          Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
          Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
          Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
          Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.