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504685 | LY 354740 - CAS 176199-48-7 - Calbiochem

504685
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₁NO₄ 176199-48-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04685.0001
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          Glass bottle 10 mg
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          Description
          OverviewA highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
          Catalogue Number504685
          Brand Family Calbiochem®
          Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
          References
          ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
          Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
          Pilc, A., 2003. IDrugs. 6, 71.
          Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
          Monn, J., 1997. J. Med. Chem. 40, 528.
          Schoepp, D., 1997. Neuropharmacol. 36, 1.
          Bond, A., 1997. Neuroreport. 8, 1463.
          Product Information
          CAS number176199-48-7
          FormWhite solid
          Hill FormulaC₈H₁₁NO₄
          Chemical formulaC₈H₁₁NO₄
          Sold on the basis of peptide contentY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetmGlu2/3 receptors
          Purity≥99% by HPLC
          Physicochemical Information
          Peptide ContentY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Siok, J., et al. 2012. Neuropharmacol. 62, 226.
          Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
          Pilc, A., 2003. IDrugs. 6, 71.
          Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
          Monn, J., 1997. J. Med. Chem. 40, 528.
          Schoepp, D., 1997. Neuropharmacol. 36, 1.
          Bond, A., 1997. Neuroreport. 8, 1463.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          Synonyms(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
          DescriptionA highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
          FormWhite solid
          CAS number176199-48-7
          Chemical formulaC₈H₁₁NO₄
          Structure formula
          Purity≥99% by HPLC
          Solubility1N NaOH (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesSiok, J., et al. 2012. Neuropharmacol. 62, 226.
          Fell, J., et al. 2012. Neuropharmacol. 62, 1473.
          Pilc, A., 2003. IDrugs. 6, 71.
          Klodzinska. A., 1999. Neuropharmacol. 38, 1831.
          Monn, J., 1997. J. Med. Chem. 40, 528.
          Schoepp, D., 1997. Neuropharmacol. 36, 1.
          Bond, A., 1997. Neuroreport. 8, 1463.