440203 | LY 303511 - CAS 154447-38-8 - Calbiochem

440203
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₈N₂O₂ 154447-38-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      440203-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
          Catalogue Number440203
          Brand Family Calbiochem®
          Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
          References
          ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
          Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
          Product Information
          CAS number154447-38-8
          ATP CompetitiveN
          FormAmber solid
          Hill FormulaC₁₉H₁₈N₂O₂
          Chemical formulaC₁₉H₁₈N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNegative control for the PI 3-kinase inhibitor LY 294002
          Primary Target IC<sub>50</sub>Does not inhibit PI 3-kinase even at a concentration of 100 µM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          440203

          References

          Reference overview
          Dittman, et al. 2014. ACS Chem Biol. 9, 495.
          Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

          Brochure

          Title
          Akt Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2007 JSW
          Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
          DescriptionA cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
          FormAmber solid
          CAS number154447-38-8
          Chemical formulaC₁₉H₁₈N₂O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
          Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.