489476 | LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

489476
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₄₀Cl₄N₈ 927019-63-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      489476-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
          Catalogue Number489476
          Brand Family Calbiochem®
          SynonymsBHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I, LSD Inhibitor I
          References
          ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
          Product Information
          CAS number927019-63-4
          FormPale yellow to yellow solid
          Hill FormulaC₁₅H₄₀Cl₄N₈
          Chemical formulaC₁₅H₄₀Cl₄N₈
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          489476

          References

          Reference overview
          Sharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2011 RFH
          SynonymsBHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I, LSD Inhibitor I
          DescriptionA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
          FormPale yellow to yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number927019-63-4
          Chemical formulaC₁₅H₄₀Cl₄N₈
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.