108378 L-Tyrosine

108378
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #EC NumberHill FormulaMolar MassGrade Value
      60-18-4 200-460-4 C₉H₁₁NO₃ 181.19 g/mol Ph Eur,JP,USP

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      1083781000
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          Plastic bottle 1 kg
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          1083789010
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              Plastic drum 10 kg
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              Description
              Catalogue Number108378
              Synonyms4-Hydroxyphenylalanine, Tyr
              References
              Product Information
              CAS number60-18-4
              EC number200-460-4
              GradePh Eur,JP,USP
              Hill FormulaC₉H₁₁NO₃
              Molar Mass181.19 g/mol
              HS Code2922 50 00
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Physicochemical Information
              Density1.46 g/cm3 (20 °C)
              Melting Point297 - 298 °C (decomposition)
              pH value6.5 (0.1 g/l, H₂O)
              Bulk density300 kg/m3
              Solubility0.38 g/l
              Dimensions
              Materials Information
              Toxicological Information
              LD 50 oralLD50 Rat > 5110 mg/kg
              Safety Information according to GHS
              RTECSYP2275600
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Disposal3
              Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +5°C to +30°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Assay (perchloric acid titration, calculated on dried substance)99.0 - 101.0 %
              Identity (IR-spectrum)passes test
              Identity (specific rotation)passes test
              Identity (UV/VIS-Spectrum)passes test
              Appearancewhite to almost white, crystalline powder or colorless crystals
              Appearance of solution (25 g/l, Hydrochloric acid 2 mol/l)clear and not more intense in color than reference solution Y₇
              Appearance of solution (50 g/l, hydrochloric acid 1 mol/l)clear and colorless
              Spec. rotation (α 20/D, 50 g/l, hydrochloric acid 1 mol/l, calc. on dried substance)-12.3 to -11.0
              Spec. rotation (α 20/D, 50 g/l, hydrochloric acid 1 mol/l, previously dried substance)-12.5 to -10.5
              Spec. rotation (α 25/D, 50 g/l, hydrochloric acid 1 mol/l, calc. on dried substance)-11.2 to -9.8
              Chloride (Cl)≤ 200 ppm
              Sulfate (SO₄)≤ 200 ppm
              Heavy metals (as Pb)≤ 10 ppm
              Fe (Iron)≤ 10 ppm
              Related Compounds, total (TLC)≤ 0.5 %
              Ninhydrin-positive substances (LC) (impurity A (570 nm))≤ 0.5 %
              Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
              Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
              Ninhydrin-positive substances (LC) (total impurities)≤ 0.6 %
              Residual solvents (ICH (Q3C))excluded by manufacturing process
              Sulfated ash (600 °C)≤ 0.1 %
              Loss on drying (105 °C; 3 h)≤ 0.3 %
              Bacterial endotoxins≤ 20 I.U./g
              Microbiological test (total aerobic microbial count (TAMC))≤ 100 CFU/g
              Microbiological test (total yeast and mould count (TYMC))≤ 100 CFU/g
              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
              Corresponds to Ph. Eur., USP

              Documentation

              Material Qualification Dossier

              Title

              Quality Management Dossier

              Title

              Operational Excellence Dossier

              Title

              L-Tyrosine SDS

              Title

              Safety Data Sheet (SDS) 

              L-Tyrosine Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              1083781000 Plastic bottlePDF Specification Document
              1083789010 Plastic drumPDF Specification Document

              Certificates

              Title

              Brochure

              Title
              Amino Acids