422720 | L-744,832 - CAS 1177806-11-9 - Calbiochem

422720
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₄₅N₃O₆S₂ · 2HCl 1177806-11-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422720-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.
          Catalogue Number422720
          Brand Family Calbiochem®
          Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
          References
          ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
          Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
          Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
          Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
          Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
          Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
          Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
          Product Information
          CAS number1177806-11-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₆H₄₅N₃O₆S₂ · 2HCl
          Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFarnesyltransferase (FTase)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          422720

          References

          Reference overview
          Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
          Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
          Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
          Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
          Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
          Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
          Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2011 RFH
          Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
          DescriptionA potent, cell-permeable, and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor that blocks p70s6k activation and DNA synthesis and promote apoptosis in transgenic mice. Induces p21 expression and arrests cell in the G1 phase of the cell cycle. Also shown to act synergistically with paclitaxel and epothilones in inhibiting tumor growth and arresting cells in metaphase. Also mimics a number of the effects exhibited by Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropirate activation of the mTOR/p70s6k pathway in animal models.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177806-11-9
          Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (25 mg/ml) or H₂O (15 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
          Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
          Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
          Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
          Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
          Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
          Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.