422175 | L-165,041 - CAS 79558-09-1 - Calbiochem

422175
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₆O₇ 79558-09-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422175-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
          Catalogue Number422175
          Brand Family Calbiochem®
          SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
          References
          ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
          Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
          Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
          Son, C., et al. 2001. Endocrinology 142, 4189.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
          Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
          Lim, H., et al. 1999. Genes Dev. 13, 1561.
          Product Information
          CAS number79558-09-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₂₆O₇
          Chemical formulaC₂₂H₂₆O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPeroxisome proliferator activator receptor δ (PPAR@delta;)
          Primary Target K<sub>i</sub>6 nM for hPPARδ and 730 nM for hPPARγ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          422175

          References

          Reference overview
          Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
          Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
          Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
          Son, C., et al. 2001. Endocrinology 142, 4189.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
          Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
          Lim, H., et al. 1999. Genes Dev. 13, 1561.

          Brochure

          Title
          Calbiochem Biologics 32.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-August-2008 RFH
          SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
          DescriptionA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPAR δ and 730 nM for hPPARγ). Induces adipocyte differentiation in NIH-PPARδ cells at 500 nM. Also reported to raise total cholesterol in insulin-resistant db/db mice without altering glucose or triglyceride levels. Shown to increase uncoupling protein 3 (UCP3) gene expression in L6 myotubes. Also shown to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and the secretion of monocyte chemotactic protein-1 (MCP-1) in Eahy926 cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number79558-09-1
          Chemical formulaC₂₂H₂₆O₇
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml) or 1 N NaOH (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
          Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
          Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
          Son, C., et al. 2001. Endocrinology 142, 4189.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
          Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
          Lim, H., et al. 1999. Genes Dev. 13, 1561.