422689 | Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

422689
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₉NO 185669-79-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422689-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
          Catalogue Number422689
          Brand Family Calbiochem®
          SynonymsInward rectifier potassium channel blocker, ML133
          References
          ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
          Product Information
          CAS number185669-79-8
          FormWhite solid
          Hill FormulaC₁₉H₁₉NO
          Chemical formulaC₁₉H₁₉NO
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          422689

          References

          Reference overview
          Lindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2012 JSW
          SynonymsInward rectifier potassium channel blocker, ML133
          DescriptionA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number185669-79-8
          Chemical formulaC₁₉H₁₉NO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml; clear, colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.