420600 | Ketoconazole - CAS 65277-42-1 - Calbiochem

420600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₈Cl₂N₄O₄ 65277-42-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420600-50MG
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          Glass bottle 50 mg
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          Description
          OverviewAn inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
          Catalogue Number420600
          Brand Family Calbiochem®
          Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
          References
          Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
          Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
          Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
          Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
          Lelcuk, S., et al. 1984. J. Trauma 24, 393.
          Product Information
          CAS number65277-42-1
          FormOff-white solid
          Hill FormulaC₂₆H₂₈Cl₂N₄O₄
          Chemical formulaC₂₆H₂₈Cl₂N₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-LO
          Primary Target IC<sub>50</sub>26 µM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSTK7912300
          Safety Information
          R PhraseR: 25-40-63-36/37/38

          Toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          Possible risk of harm to the unborn child.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420600

          References

          Reference overview
          van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
          Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
          Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
          Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
          Lelcuk, S., et al. 1984. J. Trauma 24, 393.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
          DescriptionAn inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
          FormOff-white solid
          CAS number65277-42-1
          RTECSTK7912300
          Chemical formulaC₂₆H₂₈Cl₂N₄O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 5302
          Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
          Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
          Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
          Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
          Lelcuk, S., et al. 1984. J. Trauma 24, 393.