506271 | Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem

506271
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₂FN₃O₃·C₄H₆O₆ 83846-83-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06271.0001
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          Glass bottle 50 mg
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          Description
          OverviewA selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
          Catalogue Number506271
          Brand Family Calbiochem®
          Synonyms5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
          References
          ReferencesRos, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
          Leysen, J. E. et al. 1981. Life Sci. 28, 1015.
          Product Information
          CAS number83846-83-7
          FormWhite solid
          Hill FormulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
          Chemical formulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT2A
          Primary Target K<sub>i</sub>1.49 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 46

          If swallowed, seek medical advice immediately and show this container or label.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Ros, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
          Leysen, J. E. et al. 1981. Life Sci. 28, 1015.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          Synonyms5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
          DescriptionA selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
          FormWhite solid
          CAS number83846-83-7
          Chemical formulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesRos, R. et al. 2013. PNAS. 110, 348.
          Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
          Leysen, J. E. et al. 1981. Life Sci. 28, 1015.