420321 | KT5823 - CAS 126643-37-6 - Calbiochem

420321
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₂₅N₃O₅ 126643-37-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420321-100UG
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          Plastic ampoule 100 μg
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          420321-50UG
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              Plastic ampoule 50 μg
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              Description
              OverviewHighly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
              Catalogue Number420321
              Brand Family Calbiochem®
              SynonymsPKG Inhibitor VII
              References
              ReferencesGrider, J.R. 1993. Am. J. Physiol. 264, G334.
              Product Information
              CAS number126643-37-6
              ATP CompetitiveY
              FormWhite solid
              Hill FormulaC₂₉H₂₅N₃O₅
              Chemical formulaC₂₉H₂₅N₃O₅
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetPKG
              Primary Target K<sub>i</sub>234 nM against protein kinase G
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              420321

              References

              Reference overview
              Grider, J.R. 1993. Am. J. Physiol. 264, G334.

              Citations

              Title
            • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
            • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision30-July-2008 RFH
              SynonymsPKG Inhibitor VII
              DescriptionHighly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 µM) and protein kinase A (Ki > 10.0 µM) at higher concentrations.
              FormWhite solid
              CAS number126643-37-6
              Chemical formulaC₂₉H₂₅N₃O₅
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMF or DMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesGrider, J.R. 1993. Am. J. Physiol. 264, G334.
              Citation
            • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
            • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.