533976 KLF10 Inhibitor, #48-15 - Calbiochem

533976
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₆O₅

      Pricing & Availability

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      5.33976.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable salicylate compound that binds to the second zinc finger region of KLF10 and blocks its binding to DNA and also suppresses its transcriptional activity (IC50 = 40 µM). Shown to completely eliminate the induction of luciferase activity by exogenous KLF10 (~ 100 µM). Also represses the conversion of CD4+CD25- T cells to CD4+CD25+ T regulatory cells (by 59%) and diminishes Foxp3 expression (82% at 50 µM).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533976
          Brand Family Calbiochem®
          SynonymsKruppel-Like Factor 10 Inhibitor
          References
          ReferencesKhedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.
          Product Information
          FormWhite solid
          Hill FormulaC₁₇H₁₆O₅
          Chemical formulaC₁₇H₁₆O₅
          Applications
          Biological Information
          Primary TargetKLF10
          Primary Target IC<sub>50</sub>40 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          KLF10 Inhibitor, #48-15 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Khedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-November-2015 JSW
          SynonymsKruppel-Like Factor 10 Inhibitor
          DescriptionA cell-permeable salicylate compound that binds to the second zinc finger region of KLF10 and blocks its binding to DNA and also suppresses its transcriptional activity (IC50 = 40 µM). Shown to completely eliminate the induction of luciferase activity by exogenous KLF10 (~ 100 µM). Also represses the conversion of CD4+CD25- T cells to CD4+CD25+ T regulatory cells (by 59%) and diminishes Foxp3 expression (82% at 50 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₆O₅
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKhedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.