420336 | KB-R7943 - CAS 182004-65-5 - Calbiochem

420336
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₇N₃O₃S • MeSO₃H 182004-65-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420336-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM).
          Catalogue Number420336
          Brand Family Calbiochem®
          Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
          References
          ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
          Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
          Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
          Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
          Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
          Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
          Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
          Product Information
          CAS number182004-65-5
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₁₆H₁₇N₃O₃S • MeSO₃H
          Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNa+/Ca2+ exchangers
          Primary Target IC<sub>50</sub>4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420336

          References

          Reference overview
          Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
          Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
          Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
          Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
          Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
          Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
          Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-July-2008 RFH
          Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
          DescriptionA cell-permeable inhibitor of the influx/reverse mode of the Na+/Ca2+ exchanger (NCX) (IC50 = 4.3 µM for NCX1, 4.7 µM for NCX2, and 1.4 µM for NCX3). Directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 <10 µM).
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number182004-65-5
          Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml) or H₂O (4 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
          Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
          Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
          Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
          Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
          Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
          Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.