420142 | JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 - Calbiochem

420142
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₅N₃O₂S₃ 2207-44-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420142-10MG
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          10 mg
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          Description
          OverviewA cell-permeable benzothiazole compound that inhibits JNK kinase activity (IC50 = 1.8 µM against ATF2 phosphorylation by JNK1) by competing with substrate binding (IC50 = 0.16 µM against pepJIP1 binding to JNK2), while exhibiting much reduced activity toward two other kinases (IC50 >100 µM against p38α and Akt) and two other proteases (IC50 >50 and >100 µM, respectively, against furin and LF). Shown to effectively block cellular c-Jun phosphorylation upon TNF-α stimulation even in HeLa cultures with overexpressed c-Jun substrate (IC50 = 15 µM) and display favorable stability in rat microsome (t1/2 = 70 min) as well as plasma (80% remaining after 60 min) stability assays at 37°C.
          Catalogue Number420142
          Brand Family Calbiochem®
          Synonyms2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole
          References
          ReferencesDe, S.K., et al. 2009. Bioorg. Med. Chem. 17, 2712.
          Product Information
          CAS number2207-44-5
          FormYellow solid
          Hill FormulaC₁₀H₅N₃O₂S₃
          Chemical formulaC₁₀H₅N₃O₂S₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420142

          References

          Reference overview
          De, S.K., et al. 2009. Bioorg. Med. Chem. 17, 2712.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-May-2011 RFH
          Synonyms2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole
          DescriptionA cell-permeable benzothiazole compound that inhibits JNK kinase activity (IC50 = 1.8 µM against ATF2 phosphorylation by JNK1) by competing with substrate binding (IC50 = 0.16 µM against pepJIP1 binding to JNK2), while exhibiting much reduced activity toward two other kinases (IC50 >100 µM against p38α and Akt) and two other proteases (IC50 >50 and >100 µM, respectively, against furin and LF). Shown to effectively block cellular c-Jun phosphorylation upon TNF-α stimulation even in HeLa cultures with overexpressed c-Jun substrate (IC50 = 15 µM) and display favorable stability in rat microsome (t1/2 = 70 min) as well as plasma (80% remaining after 60 min) stability assays at 37°C.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2207-44-5
          Chemical formulaC₁₀H₅N₃O₂S₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml). Insoluble in Ethanol.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesDe, S.K., et al. 2009. Bioorg. Med. Chem. 17, 2712.