420134 JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable - Calbiochem

420134
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂₅H₂₂₀N₅₂O₂₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420134-2MG
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      Stocked 
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          Plastic ampoule 2 mg
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          Description
          OverviewThe non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.
          Catalogue Number420134
          Brand Family Calbiochem®
          SynonymsH₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
          References
          ReferencesGuan, Q.H., et al. 2006. Neuroscience, 139, 609.
          Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
          Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
          Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₅H₂₂₀N₅₂O₂₇
          Chemical formulaC₁₂₅H₂₂₀N₅₂O₂₇
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetJNK
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420134

          References

          Reference overview
          Guan, Q.H., et al. 2006. Neuroscience, 139, 609.
          Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
          Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
          Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-July-2008 RFH
          SynonymsH₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
          DescriptionThe non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₂₅H₂₂₀N₅₂O₂₇
          Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGuan, Q.H., et al. 2006. Neuroscience, 139, 609.
          Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
          Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
          Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.