420129 | JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

420129
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₆N₆S 345987-15-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420129-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
          Catalogue Number420129
          Brand Family Calbiochem®
          SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
          References
          ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
          Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
          Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
          Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
          Product Information
          CAS number345987-15-7
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₂₀H₁₆N₆S
          Chemical formulaC₂₀H₁₆N₆S
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Application CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
          Biological Information
          Primary TargethJNK 1, hJNK 2, hJNK 3
          Primary Target IC<sub>50</sub>150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
          Purity≥95% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420129

          References

          Reference overview
          Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
          Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
          Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
          Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2010 RFH
          SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
          DescriptionA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number345987-15-7
          Chemical formulaC₂₀H₁₆N₆S
          Structure formulaStructure formula
          Purity≥95% by HPLC (sum of two isomers)
          SolubilityDMSO (10 mg/ml)
          CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
          Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
          Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
          Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.