420126 | JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

420126
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₃N₃O • MeSO₃H 856436-16-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420126-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
          Catalogue Number420126
          Brand Family Calbiochem®
          References
          ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
          Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.
          Product Information
          CAS number856436-16-3
          ATP CompetitiveN
          FormYellow solid
          Hill Formula C₁₈H₁₃N₃O • MeSO₃H
          Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJAK-3
          Primary Target IC<sub>50</sub>27 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420126

          References

          Reference overview
          Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
          Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

          Brochure

          Title
          Pathways and Biomarkers of JAK/STAT Signaling

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          DescriptionA cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number856436-16-3
          Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
          Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.