420122 | JAK3 Inhibitor V - CAS 932258 - Calbiochem

420122
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₀O 4452-06-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420122-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
          Catalogue Number420122
          Brand Family Calbiochem®
          Synonyms(2-Naphthylvinyl Ketone), ZM 449829
          References
          ReferencesBrown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.
          Product Information
          CAS number4452-06-6
          ATP CompetitiveN
          DeclarationSold under license of PCT Application W098/22,103.
          FormWhite waxy solid
          Hill FormulaC₁₃H₁₀O
          Chemical formulaC₁₃H₁₀O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJAK-3
          Primary Target IC<sub>50</sub>pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420122

          References

          Reference overview
          Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-July-2008 RFH
          Synonyms(2-Naphthylvinyl Ketone), ZM 449829
          DescriptionA breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
          FormWhite waxy solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number4452-06-6
          Chemical formulaC₁₃H₁₀O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesBrown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.