420101 | JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

420101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₅N₃O₃ 202475-60-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420101-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
          Catalogue Number420101
          Brand Family Calbiochem®
          Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
          References
          ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
          Product Information
          CAS number202475-60-3
          ATP CompetitiveY
          FormWhite to off-white solid
          Hill FormulaC₁₆H₁₅N₃O₃
          Chemical formulaC₁₆H₁₅N₃O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJanus family kinase 3
          Primary Target IC<sub>50</sub>78 µM against Janus family kinase 3
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420101

          References

          Reference overview
          Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
          DescriptionA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number202475-60-3
          Chemical formulaC₁₆H₁₅N₃O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.