530153 JAK2 Inhibitor X, FLLL32 - Calbiochem

530153
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₈H₃₂O₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.30153.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50 > 100 µM). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50 = 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530153
          Brand Family Calbiochem®
          SynonymsSTAT3 Signaling Inhibitor, FLLL32
          References
          ReferencesWu, J., et al. 2014. Oncogene 33,173.
          Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
          Li, L., et al. 2010. Cancer Res. 70, 2445.
          Product Information
          FormYellow powder
          Hill FormulaC₂₈H₃₂O₆
          Chemical formulaC₂₈H₃₂O₆
          ReversibleY
          Applications
          Biological Information
          Primary TargetJAK2
          Primary Target IC<sub>50</sub>5 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          JAK2 Inhibitor X, FLLL32 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wu, J., et al. 2014. Oncogene 33,173.
          Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
          Li, L., et al. 2010. Cancer Res. 70, 2445.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2014 JSW
          SynonymsSTAT3 Signaling Inhibitor, FLLL32
          DescriptionA cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 µM) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50 > 100 µM). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50 = 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₈H₃₂O₆
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWu, J., et al. 2014. Oncogene 33,173.
          Onimoe, G., et al. 2012. Invest. New Drugs 30, 916.
          Li, L., et al. 2010. Cancer Res. 70, 2445.