420355 | Isoproterenol, Hydrochloride - CAS 51-30-9 - Calbiochem

420355
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₁₇NO₃ · HCl 51-30-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420355-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewPhenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.
          Catalogue Number420355
          Brand Family Calbiochem®
          References
          ReferencesSchmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem. 275, 25342.
          Carmena, M.J., et al. 1997. Prostate 33, 46.
          Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
          Kishimoto, I., et al. 1994. J. Biol. Chem. 269, 28300.
          Macaulay, S.L., et al. 1994. Mol. Cell Biochem. 141, 27.
          Yashiro, K., et al. 1994. J. Biochem. 115, 1040.
          Ladenheim, R.G., et al. 1993. J. Neurochem. 60, 260.
          von Zastrow, M., et al. 1993. J. Biol. Chem. 268, 763.
          Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res. 10, 213.
          Product Information
          CAS number51-30-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₁H₁₇NO₃ · HCl
          Chemical formulaC₁₁H₁₇NO₃ · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetβ-adrenergic agonist
          Purity≥99% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDO1925000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420355

          References

          Reference overview
          Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem. 275, 25342.
          Carmena, M.J., et al. 1997. Prostate 33, 46.
          Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
          Kishimoto, I., et al. 1994. J. Biol. Chem. 269, 28300.
          Macaulay, S.L., et al. 1994. Mol. Cell Biochem. 141, 27.
          Yashiro, K., et al. 1994. J. Biochem. 115, 1040.
          Ladenheim, R.G., et al. 1993. J. Neurochem. 60, 260.
          von Zastrow, M., et al. 1993. J. Biol. Chem. 268, 763.
          Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res. 10, 213.

          Brochure

          Title
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          DescriptionPhenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.
          FormWhite solid
          CAS number51-30-9
          RTECSDO1925000
          Chemical formulaC₁₁H₁₇NO₃ · HCl
          Structure formulaStructure formula
          Purity≥99% by TLC
          SolubilityEthanol or H₂O
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Irritant
          Merck USA index14, 5217
          ReferencesSchmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem. 275, 25342.
          Carmena, M.J., et al. 1997. Prostate 33, 46.
          Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
          Kishimoto, I., et al. 1994. J. Biol. Chem. 269, 28300.
          Macaulay, S.L., et al. 1994. Mol. Cell Biochem. 141, 27.
          Yashiro, K., et al. 1994. J. Biochem. 115, 1040.
          Ladenheim, R.G., et al. 1993. J. Neurochem. 60, 260.
          von Zastrow, M., et al. 1993. J. Biol. Chem. 268, 763.
          Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res. 10, 213.