A part of MilliporeSigma

IL004 | Interleukin-4 Protein, Recombinant human

20 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesPurity
      CULT Human Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/μg) of IL-4.
      Catalogue NumberIL004
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-4 Protein, Recombinant human
      OverviewInterleukin-4 (IL-4) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells, recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues.
      Alternate Names
      • IL-4
      Product Information
      PresentationSterile filtered, lyophilized protein with no additives.
      ApplicationThe recombinant human Interleukin-4 protein (or IL-4 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IL-4 exerts its biological activity in the concentration range of 0.1 to 10 ng/mL. Responding cells are (partial list): B-cells and certain T-cells.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/μg) of IL-4.
      Specific ActivityHuman IL-4 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is <= 0.2 ng/mL, corresponding to a specific activity of >= 5 x 10(E6) units/mg.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
      Gene Symbol
      • IL4
      • Binetrakin
      • Pitrakinra
      • BSF1
      • BSF-1
      • IL-4
      • MGC79402
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05112 # Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
      SIZE: 153 amino acids; 17492 Da
      DISEASE: SwissProt: P05112 # Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      SIMILARITY: SwissProt: P05112 ## Belongs to the IL-4/IL-13 family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for 1 week or at -20°C for future use. Reconstituted IL-4 should be stored in undiluted aliquots at -20°C for up to six months.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2119987 2119987
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2148213 2148213
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2010064 2010064
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2090408 2090408
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2276291 2276291
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2280807 2280807
      RECOMBINANT HUMAN INTERLEUKIN-4 - 2328320 2328320
      RECOMBINANT HUMAN INTERLEUKIN-4 -2609896 2609896
      RECOMBINANT HUMAN INTERLEUKIN-4 -2728441 2728441
      RECOMBINANT HUMAN INTERLEUKIN-4 -2822769 2822769

      Data Sheet


      Related Products & Applications

      Product Families


      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors