407623 | Interleukin-2, Human, Recombinant, E. coli

407623
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407623-10UG
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          Plastic ampoule 10 μg
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          Description
          OverviewRecombinant, human interleukin-2 expressed in E. coli. Has a variety of immunological functions. IL-2 is secreted by activated T cells. Acts as an autocrine agent to promote proliferation and maturation of activated T cells. Human IL-2 is active in murine cell lines. Exhibits about 60% amino acid homology with murine IL-2. Inhibits dexamethasone-induced apoptosis in T lymphocytes. Induces nitric oxide synthase.
          Catalogue Number407623
          Brand Family Calbiochem®
          SynonymsrhIL-2
          References
          ReferencesMigliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
          Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
          Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
          Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
          Taniguchi, T., et al. 1983. Nature 302, 305.
          Product Information
          FormLyophilized
          FormulationCarrier-free
          Applications
          Biological Information
          Biological activityED₅₀= 80-500 pg/ml as measured in a cell proliferation assay with an IL-2-dependent murine cytotoxic T cell line
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤100 pg/µg IL-2
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNM9742000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407623

          References

          Reference overview
          Migliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
          Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
          Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
          Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
          Taniguchi, T., et al. 1983. Nature 302, 305.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          SynonymsrhIL-2
          DescriptionRecombinant, human interleukin-2 expressed in E. coli. Has a variety of immunological functions. Acts as an autocrine agent to promote proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows ~60% sequence similarity. Inhibits dexamethasone-induced apoptosis in T-lymphocytes. Induces nitric oxide synthase. Human IL-2 is active in murine cell lines. Validated for use in cell culture and bioassays.
          FormLyophilized
          FormulationCarrier-free
          RTECSNM9742000
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: ≤100 pg/µg IL-2
          Biological activityED₅₀= 80-500 pg/ml as measured in a cell proliferation assay with an IL-2-dependent murine cytotoxic T cell line
          SolubilityReconstitute to a concentration of 0.1-1 mg/ml with sterile 100 mM acetic acid. Further dilute in buffer or medium containing ≥0.1% BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          Merck USA index14, 4994
          ReferencesMigliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
          Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
          Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
          Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
          Taniguchi, T., et al. 1983. Nature 302, 305.