407617 | Interleukin-1β, Mouse, Recombinant, E. coli

407617
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407617-5UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 5 μg
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          Description
          OverviewRecombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing.
          Catalogue Number407617
          Brand Family Calbiochem®
          References
          ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Weidmann, B., et al. 1994. Nature 370, 434.
          Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.
          Product Information
          FormLyophilized
          FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
          Applications
          Biological Information
          Biological activityED₅₀= 5-10 pg/ml as measured in a cell proliferation assay
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNM9740000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407617

          References

          Reference overview
          Chun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Weidmann, B., et al. 1994. Nature 370, 434.
          Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          DescriptionRecombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Interleukin-1 is a protein produced by stimulated macrophages and many other cell types. The following biological activities are attributed to IL-1: activation of T cells resulting in the production of IL-2 and expression of IL-2 receptors; initiation of Acute Phase Response by induction of hepatic protein synthesis; increased proteolysis of muscle proteins, amino acid mobilization, and caloric and oxygen utilization; induction of bone resorption; stimulation of fibroblast proliferation; induction of slow-wave sleep; fever production; induction of prostaglandin and leukotriene production; stimulation of thymocyte proliferation; induction of B cell proliferation and maturation and increased immunoglobulin synthesis; induction of collagenase and other proteinases in synovial fibroblasts and articular chrondrocytes, suggesting a role in pathological states such as arthritis; activation of neutrophils. 1 µg is equivalent to 1.1 x 106 WHO units.
          FormLyophilized
          FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
          RTECSNM9740000
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
          Biological activityED₅₀= 5-10 pg/ml as measured in a cell proliferation assay
          SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Toxicity Standard Handling
          Merck USA index14, 4993
          ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Weidmann, B., et al. 1994. Nature 370, 434.
          Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.

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          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins