407615 | Interleukin-1β, Human, Recombinant, E. coli

407615
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407615-5UG
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      Stocked 
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          Plastic ampoule 5 μg
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          Description
          OverviewRecombinant, human interleukin-1β expressed in E. coli. Major form of interleukin-1 secreted by monocytes and macrophages. Induces nitric oxide synthase in pancreatic and smooth muscle cells and suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing.
          Catalogue Number407615
          Brand Family Calbiochem®
          SynonymsrhIL-1β
          References
          ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Kunz, D., et al. 1994. Biochem. J. 304, 337.
          Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
          Dinarello, C>A> 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.
          Product Information
          CAS number97599-21-8
          FormLyophilized
          FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
          Applications
          Biological Information
          Biological activityED₅₀ = <12 pg/ml as measured in a cell proliferation assay using the murine T-cell line, D10.G4.1 (Symons, J.A. et al. 1987)
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNM9740000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407615

          References

          Reference overview
          Chun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Kunz, D., et al. 1994. Biochem. J. 304, 337.
          Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
          Dinarello, C>A> 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Growth Factors and Cytokines Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          SynonymsrhIL-1β
          DescriptionRecombinant, human interleukin-1β expressed in E. coli. Major form of interleukin-1 secreted by monocytes and macrophages. IL-1β is activated by proteolytic cleavage of the precursor molecule. Increases nitric oxide production in smooth muscle cells and suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Induces nitric oxide synthase in insulin-producing cells. 1 µg of IL-1β corresponds to 1.9 x 105 WHO units.
          FormLyophilized
          FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
          CAS number97599-21-8
          RTECSNM9740000
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
          Biological activityED₅₀ = <12 pg/ml as measured in a cell proliferation assay using the murine T-cell line, D10.G4.1 (Symons, J.A. et al. 1987)
          SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Toxicity Standard Handling
          Merck USA index14, 4993
          ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
          Kunz, D., et al. 1994. Biochem. J. 304, 337.
          Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
          Dinarello, C>A> 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.

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          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins