407611 Interleukin-1α, Human, Recombinant, E. coli

407611
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      Overview

      Replacement Information

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407611-2UG
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          Plastic ampoule 2 μg
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          Description
          OverviewRecombinant, human interleukin-1α expressed in E. coli. Potent stimulator of bone resorption and stimulator of nuclear phospholipase C. Induces nitric oxide synthase.
          Catalogue Number407611
          Brand Family Calbiochem®
          References
          ReferencesTsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
          Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
          Dinarello, C.A., et al. 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
          March, C.J., et al. 1985. Nature 315, 641.
          Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.
          Product Information
          FormLyophilized
          FormulationLyophilized from sterile-filtered 20 mM Tris-HCl, 50 µg BSA/µg IL-1α, pH 8.3.
          Applications
          Biological Information
          Biological activityED₅₀ = 3-7 pg/ml as measured in a cell proliferation assay.
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1α
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNM9739900
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407611

          References

          Reference overview
          Tsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
          Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
          Dinarello, C.A., et al. 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
          March, C.J., et al. 1985. Nature 315, 641.
          Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Growth Factors and Cytokines Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          DescriptionRecombinant, human interleukin-1α expressed in E. coli. A 159 amino acid polypeptide derived from mature IL-1α. Synthesized in vivo as a 271 amino acid residue (31 kDa) precursor that is subsequently cleaved into the mature polypeptide. Shows ~25% amino acid sequence identity with IL-1β, a distinct gene product sharing the same cell surface receptors as IL-1α. Produced by activated macrophages and many other cell types, the IL-1 proteins mediate a variety of effects on the differentiation and function of many cell types involved in inflammatory and immune responses. Potent stimulator of bone resorption and stimulator of nuclear phospholipase C. Induces nitric oxide synthase. Effects include stimulation of T-cell, B-cell, neutrophil, and fibroblast proliferation; induction of prostaglandin, leukotriene, and acute-phase hepatic protein synthesis; induction of proteinases in synovial fibroblasts and articular chondrocytes. IL-1 is also known to induce fever, slow-wave sleep, and bone resorption. 1 µg is equivalent to 1.6 x 105 WHO units.
          FormLyophilized
          FormulationLyophilized from sterile-filtered 20 mM Tris-HCl, 50 µg BSA/µg IL-1α, pH 8.3.
          RTECSNM9739900
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-1α
          Biological activityED₅₀ = 3-7 pg/ml as measured in a cell proliferation assay.
          SolubilityReconstitute with sterile PBS containing ≥0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
          Toxicity Standard Handling
          Merck USA index14, 4993
          ReferencesTsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
          Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
          Dinarello, C.A., et al. 1991. Blood 77, 1627.
          Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
          Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
          March, C.J., et al. 1985. Nature 315, 641.
          Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.

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          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins