A part of MilliporeSigma

IL001 | Interleukin-1α Protein, Recombinant human

10 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesPurity
      CULT Human Greater than 98% by SDS-PAGE and HPLC analyses.
      Catalogue NumberIL001
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-1α Protein, Recombinant human
      OverviewInterleukin-1alpha is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses. Human IL-1alpha is a 18.0 kDa protein containing 159 amino acid residues.
      Alternate Names
      • IL-1alpha
      Product Information
      PresentationLyophilized from 10 mM Tris, pH 8.0, containing 50 mM NaCl.
      ApplicationThe recombinant human Interleukin-1alpha protein is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IL-1alpha exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses.
      Specific ActivityHuman IL-1alpha is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of mouse D10S cells is less than 0.001 ng/mL, corresponding to a specific activity of >=1 x 10(E9) units/mg.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
      Gene Symbol
      • IL1A
      • IL1-ALPHA
      • IL1
      • pro-interleukin-1-alpha
      • IL1F1
      • Hematopoietin-1
      • IL-1A
      • hematopoietin-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01583 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
      SIZE: 271 amino acids; 30607 Da
      SUBUNIT: Monomer.
      SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
      DOMAIN: SwissProt: P01583 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
      SIMILARITY: Belongs to the IL-1 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1 mg/mL. This solution can be diluted into other buffered solutions or stored at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Product Families


      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors