A part of MilliporeSigma

IF005 | Interferon-γ Protein, Recombinant mouse

100 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Mouse Mouse, expressed in E.coli Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IFN-gamma.
      Catalogue NumberIF005
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterferon-γ Protein, Recombinant mouse
      OverviewInterferon-gamma (IFN-gamma) is a regulatory protein produced by activated NK cells and CD4+TCRalpha/beta+, CD8+TCRalpha/beta+, and TCRgamma/delta+ T cells. The biological activities of IFN-gamma include the specific binding to a single class of high affinity receptors. In addition, IFN-gamma can upgrade the number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils. Recombinant mouse IFN-gamma is a 15.6 kDa protein containing 134 amino acid residues.
      Product Information
      PresentationSterile filtered, lyophilized from 10mM Sodium Phosphate, pH 7.0 + 25mM NaCl.
      ApplicationThe Interferon-gamma protein (or IFN-gamma protein) is a regulatory protein produced by activated NK cells & CD4+TCRalpha/beta+, CD8+TCRalpha/beta+ & TCRgamma/delta+ T cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IFN-gamma exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IFN-gamma.
      SourceMouse, expressed in E.coli
      Specific ActivityThe ED50 as determined by a cytopathic effect inhibition assay with mouse NIH 3T3 cells challenged VSV is <= 0.1 ng/mL, corresponding to a specific activity of >= 1.0 x 10E7 units/mg.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01579 # Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      SIZE: 166 amino acids; 19348 Da
      SUBUNIT: Homodimer.
      TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
      PTM: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
      DISEASE: SwissProt: P01579 # In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
      SIMILARITY: SwissProt: P01579 ## Belongs to the type II (or gamma) interferon family.
      Stem Cell Type
      • Mesenchymal Stem Cells
      • Hematopoietic Stem Cells
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized protein is stable for a few weeks at room temperature, but is best stored at -20°C. After a quick spin, reconstitute with Sodium Phosphate, pH 8.0 to a concentration of 1 mg/mL. Further dilutions should be made into RPMI + 10% FCS or 5% HAS and stored at 2-8ºC for one week or -20ºC for future use. Reconstituted IFN-gamma should be stored in undiluted aliquots at -20°C for up to six months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RECOMBINANT MOUSE INTERFERON- - 2090104 2090104
      RECOMBINANT MOUSE INTERFERON- - 2195999 2195999
      RECOMBINANT MOUSE INTERFERON- - 2283317 2283317
      RECOMBINANT MOUSE INTERFERON-#947; - 2003645 2003645
      RECOMBINANT MOUSE INTERFERON-#947; - 2043875 2043875
      RECOMBINANT MOUSE INTERFERON-gamma - LV1573184 LV1573184
      RECOMBINANT MOUSE INTERFERON-γ - 2373518 2373518
      RECOMBINANT MOUSE INTERFERON-γ - 2453142 2453142
      RECOMBINANT MOUSE INTERFERON-γ - 2493940 2493940
      RECOMBINANT MOUSE INTERFERON-γ - 2494307 2494307
      RECOMBINANT MOUSE INTERFERON-γ -2483228 2483228
      RECOMBINANT MOUSE INTERFERON-γ -2584043 2584043
      RECOMBINANT MOUSE INTERFERON-γ -2607299 2607299
      RECOMBINANT MOUSE INTERFERON-γ -2648646 2648646
      RECOMBINANT MOUSE INTERFERON-γ -2677885 2677885
      RECOMBINANT MOUSE INTERFERON-γ -2710742 2710742
      RECOMBINANT MOUSE INTERFERON-γ -2728403 2728403
      RECOMBINANT MOUSE INTERFERON-γ -2757212 2757212
      RECOMBINANT MOUSE INTERFERON-γ -2812753 2812753

      Data Sheet


      Related Products & Applications

      Product Families


      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors