407241 | Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda

407241
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407241-50UG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 50 μg
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          Description
          OverviewRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides.
          Catalogue Number407241
          Brand Family Calbiochem®
          SynonymsInsulysin, IDE
          References
          ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
          Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
          Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
          Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
          Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
          Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
          EC number3.4.24.56
          FormLiquid
          FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          Specific Activity≥3 U/mg protein
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407241

          References

          Reference overview
          Hersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
          Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
          Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
          Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
          Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
          Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.

          Brochure

          Title
          Biologics 33.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-March-2008 JSW
          SynonymsInsulysin, IDE
          DescriptionRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-α, and amyloid peptides. Reported to be inversely correlated with brain Aβ peptide levels in insulysin-deficient mice compared to wild-type mice.
          FormLiquid
          FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
          Concentration Label Please refer to vial label for lot-specific concentration
          EC number3.4.24.56
          Purity≥90% by SDS-PAGE
          Specific activity≥3 U/mg protein
          Unit definitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
          Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
          Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
          Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
          Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
          Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.