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405268 | Indomethacin - CAS 53-86-1 - Calbiochem

405268
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₆ClNO₄ 53-86-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      405268-10GM
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          Alu drum 10 gm
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          Description
          OverviewA non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
          Catalogue Number405268
          Brand Family Calbiochem®
          Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
          References
          ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
          Weggen, S., et al. 2001. Nature 414, 212.
          Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
          Oliw, E. 1980. Prostaglandins 19, 271.
          Product Information
          CAS number53-86-1
          ATP CompetitiveN
          FormWhite to off-white powder
          Hill FormulaC₁₉H₁₆ClNO₄
          Chemical formulaC₁₉H₁₆ClNO₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1
          Primary Target IC<sub>50</sub>740 nM
          Purity≥98% by assay
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNL3500000
          Safety Information
          R PhraseR: 28-42/43-63

          Very toxic if swallowed.
          May cause sensitization by inhalation and skin contact.
          Possible risk of harm to the unborn child.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          405268

          References

          Reference overview
          Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
          Weggen, S., et al. 2001. Nature 414, 212.
          Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
          Oliw, E. 1980. Prostaglandins 19, 271.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
          DescriptionA cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Reported to reduce Aβ42 levels independently of COX activity.
          FormWhite to off-white powder
          CAS number53-86-1
          RTECSNL3500000
          Chemical formulaC₁₉H₁₆ClNO₄
          Structure formula
          Purity≥98% by assay
          SolubilityEthanol (20 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 4968
          ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
          Weggen, S., et al. 2001. Nature 414, 212.
          Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Futaki, N., et al. 1994. Prostaglandins 47, 55.
          Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
          Oliw, E. 1980. Prostaglandins 19, 271.