402086 | Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

402086
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀IN₃O₂ 331467-03-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      402086-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
          Catalogue Number402086
          Brand Family Calbiochem®
          References
          ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
          Product Information
          CAS number331467-03-9
          ATP CompetitiveY
          FormDark red solid
          Hill FormulaC₁₆H₁₀IN₃O₂
          Chemical formulaC₁₆H₁₀IN₃O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGsk-3β
          Primary Target IC<sub>50</sub>9 nM against GSK-3β
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          402086

          References

          Reference overview
          Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          DescriptionA highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
          FormDark red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331467-03-9
          Chemical formulaC₁₆H₁₀IN₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.