688002 InSolution™ Y-27632 in DMSO - Calbiochem

688002
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₂₁N₃O•2HCl•H₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      688002-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
          Catalogue Number688002
          Brand Family Calbiochem®
          Synonyms(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
          References
          ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Chitaley, K., et al. 2001. Nat. Med. 7, 119.
          Davies, S.P., et al. 2000. Biochem. J. 351, 95.
          Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
          Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
          Maekawa, M., et al. 1999. Science 285, 895.
          Uehata, M., et al. 1997. Nature 389, 990.
          Product Information
          FormLiquid
          FormulationA 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
          Hill FormulaC₁₄H₂₁N₃O•2HCl•H₂O
          Chemical formulaC₁₄H₂₁N₃O•2HCl•H₂O
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Y-27632 in DMSO - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Y-27632 in DMSO - Calbiochem Certificates of Analysis

          TitleLot Number
          688002

          References

          Reference overview
          Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Chitaley, K., et al. 2001. Nat. Med. 7, 119.
          Davies, S.P., et al. 2000. Biochem. J. 351, 95.
          Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
          Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
          Maekawa, M., et al. 1999. Science 285, 895.
          Uehata, M., et al. 1997. Nature 389, 990.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-January-2012 RFH
          Synonyms(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
          DescriptionA highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
          FormLiquid
          FormulationA 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
          Chemical formulaC₁₄H₂₁N₃O•2HCl•H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Chitaley, K., et al. 2001. Nat. Med. 7, 119.
          Davies, S.P., et al. 2000. Biochem. J. 351, 95.
          Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
          Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
          Maekawa, M., et al. 1999. Science 285, 895.
          Uehata, M., et al. 1997. Nature 389, 990.