584223 InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem

584223
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₆N₂O₆ • 2H₂O 18771-50-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      584223-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
          Catalogue Number584223
          Brand Family Calbiochem®
          SynonymsTHU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
          References
          ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
          Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
          Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
          Riva, C., et al. 1992. Chemotherapy 38, 358.
          Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
          Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
          Product Information
          CAS number18771-50-1
          FormLiquid
          FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
          Hill FormulaC₉H₁₆N₂O₆ • 2H₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcytidine deaminase
          Purity≥90% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          584223

          References

          Reference overview
          Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
          Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
          Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
          Riva, C., et al. 1992. Chemotherapy 38, 358.
          Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
          Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-January-2019 JSW
          SynonymsTHU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
          DescriptionA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
          FormLiquid
          FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number18771-50-1
          Structure formulaStructure formula
          Purity≥90% by TLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Standard Handling
          ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
          Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
          Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
          Riva, C., et al. 1992. Chemotherapy 38, 358.
          Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
          Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.