565794 InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

565794
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₃₈N₄O₅S 797035-11-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565794-500UG
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          Glass bottle 500 μg
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          Description
          OverviewA cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.
          Catalogue Number565794
          Brand Family Calbiochem®
          SynonymsN-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide
          References
          ReferencesStachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
          Product Information
          CAS number797035-11-1
          FormLiquid
          FormulationA 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.
          Hill FormulaC₃₁H₃₈N₄O₅S
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetβ-Secretase
          Primary Target IC<sub>50</sub>15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          565794

          References

          Reference overview
          Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          SynonymsN-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide
          DescriptionA cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.
          FormLiquid
          FormulationA 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number797035-11-1
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesStachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.