553212 InSolution™ Rapamycin in EtOH

553212
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅₁H₇₉NO₁₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553212-1MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Glass bottle 1 mg
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          Description
          Catalogue Number553212
          Brand Family Calbiochem®
          SynonymsSirolimus, mTOR Inhibitor I
          References
          ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
          Product Information
          FormLiquid
          FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
          Hill FormulaC₅₁H₇₉NO₁₃
          Chemical formulaC₅₁H₇₉NO₁₃
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 11

          Highly flammable.
          S PhraseS: 16-7

          Keep away from sources of ignition - No Smoking.
          Keep container tightly closed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Rapamycin in EtOH SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Rapamycin in EtOH Certificates of Analysis

          TitleLot Number
          553212

          References

          Reference overview
          Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-September-2008 JSW
          SynonymsSirolimus, mTOR Inhibitor I
          DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 0.05 nM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
          FormLiquid
          FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅₁H₇₉NO₁₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Flammable
          Merck USA index14, 8114
          ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
          Braun, W., et al. 1995. FASEB J. 9, 63.
          Nielsen, F.C., et al. 1995. Nature 377, 358.
          Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
          Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
          Kuo, J., et al. 1992. Nature 358, 70.
          Price, D.J., et al. 1992. Science 257, 973.
          Heitman, J., et al. 1991. Science 253, 905.
          Kay, J.E., et al. 1991. Immunology 72, 544.
          Schreiber, S.L. 1991. Science 251, 283.
          Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
          Dumont, F.J., et al. 1990. J. Immunol. 144, 251.