553211 InSolution™ Rapamycin - Calbiochem

553211
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅₁H₇₉NO₁₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553211-1MG
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          Plastic ampoule 1 mg
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          553211-500UG
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              Plastic ampoule 500 μg
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              Description
              Catalogue Number553211
              Brand Family Calbiochem®
              SynonymsmTOR Inhibitor I
              References
              Product Information
              ATP CompetitiveN
              FormLiquid
              FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
              Hill FormulaC₅₁H₇₉NO₁₃
              Chemical formulaC₅₁H₇₉NO₁₃
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetMammalian target of rapamycin (mTOR)
              Primary Target IC<sub>50</sub>50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
              Purity≥98% by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Irritant
              Storage -20°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              InSolution™ Rapamycin - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              InSolution™ Rapamycin - Calbiochem Certificates of Analysis

              TitleLot Number
              553211

              Brochure

              Title
              Calbiochem Biologics 32.2
              In Solution!" Product Flyer

              Citations

              Title
            • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
            • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
            • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision09-September-2008 RFH
              SynonymsmTOR Inhibitor I
              DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
              FormLiquid
              FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₅₁H₇₉NO₁₃
              Structure formulaStructure formula
              Purity≥98% by TLC
              Storage -20°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
              Toxicity Irritant
              Citation
            • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
            • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
            • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.