553508 InSolution™ Rac1 Inhibitor - Calbiochem

553508
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₃₅N₇ • 3HCl

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553508-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Catalogue Number553508
          Brand Family Calbiochem®
          References
          ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
          Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
          Hill FormulaC₂₄H₃₅N₇ • 3HCl
          Chemical formulaC₂₄H₃₅N₇ • 3HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRac1
          Primary Target IC<sub>50</sub>~50 µM interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Rac1 Inhibitor - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Rac1 Inhibitor - Calbiochem Certificates of Analysis

          TitleLot Number
          553508

          References

          Reference overview
          Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
          Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

          Brochure

          Title
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-December-2010 JSW
          DescriptionA cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
          FormLiquid
          FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₃₅N₇ • 3HCl
          Structure formulaStructure formula
          Purity≥93% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
          Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.