551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

551476
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₆H₂₅F₂N₃O₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      551476-1MG
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          Plastic ampoule 1 mg
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          551476-5MG
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              Glass bottle 5 mg
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              Description
              OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
              Catalogue Number551476
              Brand Family Calbiochem®
              SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
              References
              ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
              Caserta, T.M., et al. 2003. Apoptosis 8, 345.
              Rebbaa, A., et al. 2003. Oncogene 22, 2805.
              Product Information
              ATP CompetitiveN
              FormLiquid
              FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
              Hill FormulaC₂₆H₂₅F₂N₃O₆
              Chemical formulaC₂₆H₂₅F₂N₃O₆
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetcaspase-1
              Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceQ-Val-Asp-CH₂-OPh
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Irritant
              Storage -20°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem Certificates of Analysis

              TitleLot Number
              551476

              References

              Reference overview
              Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
              Caserta, T.M., et al. 2003. Apoptosis 8, 345.
              Rebbaa, A., et al. 2003. Oncogene 22, 2805.

              Brochure

              Title
              In Solution!" Product Flyer

              Citations

              Title
            • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
            • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
            • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision28-February-2012 RFH
              SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
              DescriptionA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50 nM for caspase-1; IC50 = 100 nM for caspase-8; IC50 = 430 nM for caspase-9; IC50 < 25 nM for caspase-3). Exhibits effective anti-apoptotic properties against all major caspase-mediated cellular apoptosis pathways, including caspase 9/3, caspase 8/10, and caspase 12. Does not exhibit toxic effects even at high concentrations. To reduce hydrophobicity of the peptide and facilitate its use in aqueous media the aspartyl residue is not O-methylated. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
              FormLiquid
              FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₂₆H₂₅F₂N₃O₆
              Peptide SequenceQ-Val-Asp-CH₂-OPh
              Structure formulaStructure formula
              Purity≥90% by HPLC
              Storage -20°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
              Toxicity Irritant
              ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
              Caserta, T.M., et al. 2003. Apoptosis 8, 345.
              Rebbaa, A., et al. 2003. Oncogene 22, 2805.
              Citation
            • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
            • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
            • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.