527451 InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem

527451
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₈N₄OS 608512-97-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      527451-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.
          Catalogue Number527451
          Brand Family Calbiochem®
          SynonymsDouble-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I, C16
          References
          ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Product Information
          CAS number608512-97-6
          FormLiquid
          FormulationA 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.
          Hill FormulaC₁₃H₈N₄OS
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKR
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          527451

          References

          Reference overview
          Zhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          SynonymsDouble-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I, C16
          DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.
          FormLiquid
          FormulationA 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number608512-97-6
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
          Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.