513036 | InSolution™ PD 158780 - CAS 171179-06-9 - Calbiochem

513036
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₂BrN₅ 171179-06-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513036-500UG
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          Plastic ampoule 500 μg
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          Description
          Catalogue Number513036
          Brand Family Calbiochem®
          References
          ReferencesCunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
          Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.
          Product Information
          CAS number171179-06-9
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513035) in DMSO.
          Hill FormulaC₁₄H₁₂BrN₅
          Chemical formulaC₁₄H₁₂BrN₅
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGFR
          Primary Target IC<sub>50</sub> 8 pM against EGFR tyrosine kinase activity; 49 nM, 52 nM, against heregulin-stimulated autophosphorylation in SK-BR-3 and MDA-MB-453 breast carcinomas, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513036

          References

          Reference overview
          Cunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
          Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.

          Brochure

          Title
          Calbiochem Biologics 32.2
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2007 JSW
          DescriptionA potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
          FormLiquid
          FormulationA 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513035) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number171179-06-9
          Chemical formulaC₁₄H₁₂BrN₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesCunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
          Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.