496000 | InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem

496000
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₁H₆₄N₈O₁₄ 314266-76-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      496000-250UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 250 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewAn eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
          Catalogue Number496000
          Brand Family Calbiochem®
          SynonymsEVNLΨAAEF
          References
          ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
          Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
          Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
          Hong, L., et al. 2000. Science 290,150.
          Product Information
          CAS number314266-76-7
          ATP CompetitiveN
          FormLiquid
          FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
          Hill FormulaC₄₁H₆₄N₈O₁₄
          Chemical formulaC₄₁H₆₄N₈O₁₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targethuman brain memapsin 2
          Primary Target K<sub>i</sub>1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          496000

          References

          Reference overview
          Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
          Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
          Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
          Hong, L., et al. 2000. Science 290,150.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          SynonymsEVNLΨAAEF
          DescriptionA peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM).
          FormLiquid
          FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number314266-76-7
          Chemical formulaC₄₁H₆₄N₈O₁₄
          Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
          Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
          Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
          Hong, L., et al. 2000. Science 290,150.