481407 | InSolution™ NF-κB Activation Inhibitor - Calbiochem

481407
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₂₀N₄O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481407-1MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic Bag(s) 1 mg
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          Description
          Catalogue Number481407
          Brand Family Calbiochem®
          References
          ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
          Hill FormulaC₂₂H₂₀N₄O
          Chemical formulaC₂₂H₂₀N₄O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNF-κB transcriptional activation
          Primary Target IC<sub>50</sub>11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          481407

          References

          Reference overview
          Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Biologics 33.2
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          DescriptionA cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
          FormLiquid
          FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₂₀N₄O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Toxic
          ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.