475821 | InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem

475821
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₉H₇₄N₁₀O₁₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475821-250UG
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      Limited AvailabilityLimited Availability
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          Plastic Bag(s) 250 μg
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          Description
          Catalogue Number475821
          Brand Family Calbiochem®
          References
          ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
          Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
          Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
          Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
          Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
          Cohen, P., et al. 1989. FEBS Lett. 250, 596.
          Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.
          Product Information
          ATP CompetitiveN
          DeclarationNot available for sale outside of the United States.
          FormLiquid
          FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
          Hill FormulaC₄₉H₇₄N₁₀O₁₂
          Chemical formulaC₄₉H₇₄N₁₀O₁₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
          Primary Target IC<sub>50</sub>1.7 nM, 40 pM, against protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          End use certificateY
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475821

          References

          Reference overview
          Craig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
          Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
          Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
          Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
          Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
          Cohen, P., et al. 1989. FEBS Lett. 250, 596.
          Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.

          Brochure

          Title
          DNA Repair Pathway Poster
          In Solution!" Product Flyer

          Technical Info

          Title
          EMD Millipore Regulated Product Information
          End Use Certificate - CWC - Regulated Products
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-August-2008 RFH
          DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
          FormLiquid
          FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₉H₇₄N₁₀O₁₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Highly Toxic
          ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
          Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
          Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
          Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
          Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
          Cohen, P., et al. 1989. FEBS Lett. 250, 596.
          Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.