401485 InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem

401485
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉H₈N₂OS₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401485-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Catalogue Number401485
          Brand Family Calbiochem®
          References
          ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
          Product Information
          ATP CompetitiveY
          FormClear to pale yellow Liquid
          FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
          Hill FormulaC₉H₈N₂OS₂
          Chemical formulaC₉H₈N₂OS₂
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKK-2
          Primary Target IC<sub>50</sub>~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401485

          References

          Reference overview
          Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
          FormClear to pale yellow Liquid
          FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉H₈N₂OS₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Irritant
          ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
          Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.