Key Specifications Table
|Empirical Formula||CAS #|
Pricing & Availability
An invalid quantity was specified. The product quantity has been adjusted.
|373403-2MG||Glass bottle||2 mg||
|Overview||A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available.|
|Synonyms||2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline), NSC 136476|
|References||Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.|
|Formulation||A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO.|
|Structure formula Image|
|Primary Target||Gli1 and Gli2|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|R Phrase||R: 36/38
Irritating to eyes and skin.
|S Phrase||S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.