365253 InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem

365253
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₁₈N₄O 136194-77-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      365253-1ML
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          Plastic ampoule 1 ml
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          Description
          Catalogue Number365253
          Brand Family Calbiochem®
          SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
          References
          ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
          Product Information
          CAS number136194-77-9
          ATP CompetitiveY
          FormLiquid
          FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
          Hill FormulaC₂₄H₁₈N₄O
          Chemical formulaC₂₄H₁₈N₄O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          365253

          References

          Reference overview
          Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.

          Brochure

          Title
          In Solution!" Product Flyer
          PKC Pathway Poster PDF ( 676 KB )

          Citations

          Title
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-July-2008 RFH
          SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
          DescriptionInhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
          FormLiquid
          FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number136194-77-9
          Chemical formulaC₂₄H₁₈N₄O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
          Citation
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.