508739 InSolution™ Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

508739
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₃NO₄ 66-81-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08739.0001
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          Glass bottle 100 mg
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          Description
          Catalogue Number508739
          Brand Family Calbiochem®
          Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Product Information
          CAS number66-81-9
          FormLiquid
          FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targettranslocase enzyme
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 28-51/53-61

          Very toxic if swallowed.
          Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
          May cause harm to the unborn child.
          S PhraseS: 45-53-61

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2014 JSW
          Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
          DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
          FormLiquid
          FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
          CAS number66-81-9
          Chemical formulaC₁₅H₂₃NO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.